I just read another article suggesting that long term use of antipsychotic increases psychotic symptoms and worsens outcomes in schizophrenics. Now there are a lot of problems with the study- no randomization- maybe schizophrenics given more antipsychotics were "crazier" to begin with. But it is not good, not what you want to here if you are a psychopharmacologist.
As an OT, neuroplasticity is a good thing. It is how people can adjust to a nerve injury or a stroke. In psychopharmacology, it can mean that what a drug does in the first weeks or even months is the exact opposite of what it does over years of use. The brain adapts. Block dopamine receptors? The brain becomes super-sensitive to dopamine. Flood the brain with serotonin? The serotonin receptors down-regulate.
We don't need six week studies on drugs that we put people on for a life time. We need six year studies. Sixty years studies. Studies to show us if we are doing more harm than good.
A study recently came out showing that cortisone injections for tennis elbow had some limited short term efficacy but worsened long term outcomes. I wouldn't get a steroid injection for tennis elbow. But I suspect that some of the drugs we take in psychiatry are the equivalent of getting that steroid injection.